Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics: Concept and Applications

　　Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

　　•Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.

　　•An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.

　　•Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.

　　•More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.

　　•New and updated examples connect chapter content to real-world settings.

　　•Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.

　　•eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
 

作者簡介

Hartmut Derendorf Ph.D.

　　Distinguished Professor Emeritus
　　Department of Pharmaceutics
　　College of Pharmacy
　　University of Florida
　　Gainesville, Florida

Stephan Schmidt Ph.D

　　Certara Professor
　　Associate Professor
　　Associate Director, Center for Pharmacometrics and Systems Pharmacology
　　Department of Pharmaceutics
　　College of Pharmacy
　　University of Florida
　　Orlando, Florida
 

Section 1  Basic Considerations
Chapter 1  Therapeutic Relevance
Chapter 2  Fundamental Concepts and Terminology

Section 2  Exposure and Response after a Single Dose
Chapter 3  Kinetics Following an Intravenous Bolus Dose
Chapter 4  Membranes and Distribution
Chapter 5  Elimination
Chapter 6  Kinetics Following an Extravascular Dose
Chapter 7  Absorption
Chapter 8  Response

Section 3  Therapeutic Regimens
Chapter 9  Therapeutic Window
Chapter 10  Constant-Rate Input
Chapter 11  Multiple-Dosage Regimens

Section 4  Individualization
Chapter 12  Variability
Chapter 13  Genetics
Chapter 14  Age, Weight, and Gender
Chapter 15  Disease
Chapter 16  Nonlinearities
Chapter 17  Drug Interactions
Chapter 18  Initiating and Managing Therapy

Section 5  Supplement Topics
Chapter 19  Distribution Kinetics
Chapter 20  Metabolites and Drug Response
Chapter 21  Protein Drugs
Chapter 22  Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data

Appendices
Appendix A
Appendix B
Appendix C
Appendix D
Appendix E
Appendix F
Appendix G
Appendix H
Appendix I
Appendix J
Appendix K
Index